The circadian clock in the kidney.

@article{Stow2011TheCC,
  title={The circadian clock in the kidney.},
  author={Lisa Rebecca Stow and Michelle L. Gumz},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2011},
  volume={22 4},
  pages={
          598-604
        }
}
Circadian variations in renal function were first described in the 19th century, and GFR, renal blood flow, urine production, and electrolyte excretion exhibit daily oscillations. These clinical observations are well established, but the underlying mechanisms that govern circadian fluctuations in kidney are not fully understood. Here we provide a brief overview of the machinery governing the circadian clock and examine the clinical and molecular evidence supporting a critical role for circadian… CONTINUE READING
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