The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

@article{Habbig2012TheCD,
  title={The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.},
  author={Sandra Habbig and Malte P. Bartram and Josef G. S{\"a}gm{\"u}ller and Anabel Griessmann and Mareike Franke and Roman-Ulrich M{\"u}ller and Ricarda Schwarz and Martin Hoehne and Carsten Bergmann and Claudia Tessmer and Hans Christian Reinhardt and Volker Burst and Thomas Benzing and Bernhard Schermer},
  journal={Human molecular genetics},
  year={2012},
  volume={21 26},
  pages={5528-38}
}
Nephronophthisis (NPH) is a genetically heterogenous kidney disease and represents the most common genetic cause for end-stage renal disease in children. It is caused by the mutation of genes encoding for the nephrocystin proteins (NPHPs) which localize to primary cilia or centrosomes, classifying this disease as a 'ciliopathy'. Recently, it has been shown that NPHP4 acts as a potent negative regulator of mammalian Hippo signalling by interacting with the Lats protein kinase and controlling the… CONTINUE READING
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