The ciliopathies: an emerging class of human genetic disorders.
@article{Badano2006TheCA, title={The ciliopathies: an emerging class of human genetic disorders.}, author={J. Badano and N. Mitsuma and P. Beales and N. Katsanis}, journal={Annual review of genomics and human genetics}, year={2006}, volume={7}, pages={ 125-48 } }
Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell surfaces to perform diverse biological roles, including whole-cell locomotion; movement of fluid; chemo-, mechano-, and photosensation; and sexual reproduction. Consistent with their stringent evolutionary conservation, defects in cilia are associated with a range of human diseases, such as primary ciliary dyskinesia, hydrocephalus, polycystic liver and kidney disease, and some forms of retinal… Expand
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