The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.

@article{CaparrsMartn2013TheCE,
  title={The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.},
  author={Jos{\'e} Antonio Caparr{\'o}s-Mart{\'i}n and Mar{\'i}a Concepci{\'o}n Chamorro Valencia and Edel Reytor and Mar{\'i}a Isabel Pacheco and Margarita Fernandez and Antonio P{\'e}rez-Ayt{\'e}s and Esther Ge{\'a}n and Pablo Lapunzina and Hugues Peters and Judith A. Goodship and Victor L. Ruiz-P{\'e}rez},
  journal={Human molecular genetics},
  year={2013},
  volume={22 1},
  pages={
          124-39
        }
}
Hedgehog (Hh) signaling is involved in patterning and morphogenesis of most organs in the developing mammalian embryo. Despite many advances in understanding core components of the pathway, little is known about how the activity of the Hh pathway is adjusted in organ- and tissue-specific developmental processes. Mutations in EVC or EVC2 disrupt Hh signaling in tooth and bone development. Using mouse models, we show here that Evc and Evc2 are mutually required for localizing to primary cilia and… CONTINUE READING
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