The chronic spinalized cat: a model for neuromuscular plasticity.

  title={The chronic spinalized cat: a model for neuromuscular plasticity.},
  author={Judith L. Smith and V. Reggie Edgerton and Earl Eldred and Ronald F. Zernicke},
  journal={Birth defects original article series},
  volume={19 4},
The ability of the hindlimbs to produce weight-supported locomotion on a motorized treadmill was assessed in cats spinalized (T12) at 2 or 12 weeks of age. The animals were assigned at random to nonexercised (NE) or exercised (E) groups, the latter being trained to walk on the treadmill for 30 minutes, five-times weekly. During the four-month recovery period, spontaneous clonus at 8 to 12 Hz and hyperactive cutaneous reflexes developed in all animals. Age of spinalization had an effect on the… CONTINUE READING