The chronic mononucleosis syndrome.

@article{Straus1988TheCM,
  title={The chronic mononucleosis syndrome.},
  author={Stephen E. Straus},
  journal={The Journal of infectious diseases},
  year={1988},
  volume={157 3},
  pages={
          405-12
        }
}
  • S. Straus
  • Published 1988
  • Medicine
  • The Journal of infectious diseases
In January 1985, two reports captured the attention of the lay and medical communities by suggesting that a chronic illness characterized by fatigue is associated with unusual serological responses to Epstein-Barr virus (EBV) antigens [1, 2]. Those reports unleashed countless demands for serological testing and consultations by infectious disease specialists. In the ensuing three years the merits and deficiencies of the hypothesis that EBV infection is associated with chronic fatigue have been… Expand

References

SHOWING 1-10 OF 41 REFERENCES
A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause?
TLDR
Fifteen case-patients were identified who had severe, persistent fatigue of undetermined etiology for more than two months, and these 15 patients had significantly higher antibody titers against various components of EBV and against cytomegalovirus and herpes simplex and measles viruses. Expand
Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection.
TLDR
It is believed that the Epstein-Barr virus may be associated with chronic illness in adults and the activity of 2-5 oligoadenylate synthetase, an interferon-induced enzyme, was increased in 5 patients studied. Expand
Chronic Epstein-Barr virus infection associated with fever and interstitial pneumonitis. Clinical and serologic features and response to antiviral chemotherapy.
TLDR
Two patients developed fever, interstitial pneumonitis, and pancytopenia associated with extremely high titers of antibody to replicative antigens of the Epstein-Barr virus and provide additional evidence that acyclovir may play a role in therapy for selected patients with Epstein-barr virus infection. Expand
Heterogeneity of immune defects in three children with a chronic active Epstein-Barr virus infection
TLDR
It was concluded that each patient has his or her own peculiar defect in the virus-host balance, indicating that heterogeneity may underlie the syndrome of chronic active EBV infection in humans. Expand
Immunological reason for chronic ill health after infectious mononucleosis.
TLDR
In a group of patients who suffered from chronic ill health after an attack of acute infectious mononucleosis a disorder of T cell regulation was found, which was associated with return to normal of the lymphocyte subsets. Expand
Brucellosis. II. Medical aspects of delayed convalescence.
TLDR
Four clinical types of brucellosis were described by Hughes in his classical monograph on "Mediterranean, Malta, or Undulant Fever" and became widely accepted regardless of the species of Brucella causing infection. Expand
PROLONGED ATYPICAL ILLNESS ASSOCIATED WITH SEROLOGICAL EVIDENCE OF PERSISTENT EPSTEIN-BARR VIRUS INFECTION
TLDR
Serological and clinical observations in these patients suggest that the prolonged atypical illness was probably the result of persistent EBV infection. Expand
EB or not EB--that is the question.
TLDR
The ability of EBV to reactivate, as reflected by rates of virus shedding in the saliva and levels of antibodies to EBV antigens, depends inversely on the integrity of the cellular immune system. Expand
Epstein-Barr virus-associated hemophagocytic syndrome: virological and immunopathological studies.
TLDR
The observations suggest that EBV-induced VAHS may be the result of an increased virus burden in the face of immunoregulatory cell imbalances. Expand
The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia.
  • E. Acheson
  • Medicine
  • The American journal of medicine
  • 1959
TLDR
A number of obscure outbreaks of paralytic illness are reviewed, the majority of which were at first confused with poliomyelitis but which were later differentiated on clinical and epidemiologic grounds. Expand
...
1
2
3
4
5
...