The chronic fatigue syndrome – an update

  title={The chronic fatigue syndrome – an update},
  author={Vegard Bruun Bratholm Wyller},
  journal={Acta Neurologica Scandinavica},
  • V. Wyller
  • Published 1 May 2007
  • Medicine
  • Acta Neurologica Scandinavica
Background –  In this article, current scientific knowledge on the chronic fatigue syndrome (CFS) is reviewed. The US case definition of CFS (the CDC‐definition) is most widespread in research and clinical practice. Estimates of prevalence vary from 0.2% to above 2%. The female–male ratio is approximately 3:1. 

Chronic fatigue syndrome: An update for psychiatrists

The aim of this review is to make psychiatrists aware of the existence of CFS and that they will, one day, be confronted with the management of this illness.

Identifying and managing chronic fatigue syndrome

‘CFS’ will be used as an umbrella term to refer to chronic post-viral fatigue, and certain groups have argued for ME to be recognized as a separate condition, but this is controversial.

Chronic Fatigue and Postinfective Fatigue Syndromes

Studies with patients with the overlapping clinical syndrome of fibromyalgia have demonstrated the benefit of a combination of a low-dose tricyclic antidepressant and a nonsteroidal anti-inflammatory agent, arguing for a similar therapeutic trial in patients with chronic fatigue syndrome in whom pain and sleep disturbance are prominent.

Minireview for Chronic Fatigue Syndrome and its Medical Attention recently

  • C. Son
  • Medicine, Psychology
  • 2019
CFS is the most severe condition among fatigue-associated disease, which impairs seriously quality of life in aspects of physical, mental, and occupational wellbeing, and is related with high risk of suicide by seven fold.

Chronic fatigue syndrome: aetiology, diagnosis and treatment

The main social and care needs for people affected with Chronic Fatigue Syndrome are pointed out to point out to prevent the problems derived from current systems.

A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease

It is difficult to establish the role of mitochondria in the pathomechanisms of ME/CFS/SEID due to inconsistencies across the studies, and future well-designed studies using the same ME/ CFS/ SEID diagnostic criteria and analysis methods are required.

Case Report of Chronic Fatigue Syndrome Treated with Salt-Indirect Moxibustion

  • C. Son
  • Medicine, Psychology
  • 2012
A male patient with severe CFS was treated with mainly indirect moxibustion and the patient’s symptoms matched the criteria for CFS diagnosis, and the fatigue feeling and related-symptoms were radically reduced by 14-day treatment.

A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis

There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME, and Recommendations for future research in this field include the use of consistent criteria for the diagnosis of C FS/ME.

Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities

“ME/CFS” does not exist and cannot be replaced by a new clinical entity (SEID: Systemic Exertion Intolerance Disease, as recently suggested), due to the definitions of ME and CFS.



Chronic Fatigue Syndrome

  • S. Wessely
  • Psychology
    BMJ : British Medical Journal
  • 2000
The conceptual model of CFS needs to be changed from one determined by a single cause/agent to one in which dysfunction is the end stage of a multifactorial process.

Neuropsychological functioning in chronic fatigue syndrome: a review

The current status of neurocognitive studies in patients with chronic fatigue syndrome (CFS) is reviewed critically to assess the need for further studies into the role of emotion regulation and language impairment in the development of CFS.

Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology

The recent findings suggest that further research is needed in improving the current case definition; investigating overlaps and boundaries among various functional somatic syndromes; answering the question of whether the pathophysiologic findings are a cause or consequence; and elucidating the involvement of the central nervous system, immune system and genetic factors.

Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols

A systematic clinical working case definition for myalgic encephalomyelitis is presented and an Ex- pert Medical Consensus Panel representing treating physicians, teaching faculty and researchers are selected.

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons

A systematic review describing the prognosis of chronic fatigue syndrome.

Full recovery from untreated CFS is rare, however, there is increasing evidence for the effectiveness of cognitive behavioural and graded exercise therapies and medical retirement should be postponed until a trial of such treatment has been given.

A community-based study of chronic fatigue syndrome.

Earlier findings suggesting that CFS is a syndrome primarily affecting white, middle-class patients were not supported, and the highest levels of CFS were consistently found among women, minority groups, and persons with lower levels of education and occupational status.

Prevalence of chronic fatigue syndrome in an Australian population

An epidemiological study was undertaken to provide the first reported estimate of the point prevalence of chronic fatigue syndrome in an Australian community, and suggests a prevalence on June 30 1988 of 37.1 cases per 100 000 (95% confidence interval [Cl], 26.8‐50).

Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas.

Chronic fatigue syndrome constitutes a major public health problem and longitudinal follow-up of this cohort will be used to further evaluate the natural history of this illness.