The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism

@article{Longo1997TheCM,
  title={The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism},
  author={Letizia Longo and Anne E. Bygrave and Frank G. Grosveld and Pier Paolo Pandolfi},
  journal={Transgenic Research},
  year={1997},
  volume={6},
  pages={321-328}
}
Mouse pluripotent embryonic stem (ES) cells, once reintroduced into a mouse blastocyst, can contribute to the formation of all tissues, including the germline, of an organism referred to as a chimaeric. However, the reasons why this contribution often appears erratic are poorly understood. We have tested the notion that the chromosome make-up may be important in contributing both to somatic cell chimaerism and to germ line transmission. We found that the percentage of chimaerism of ES cell… CONTINUE READING
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