The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man

  title={The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man},
  author={M. Lewis and H. Kaita and G. Coghlan and S. Philipps and E. Belcher and P. Mcalpine and G. Coopland and R. A. Woods},
  journal={Annals of Human Genetics},
  • M. Lewis, H. Kaita, +5 authors R. A. Woods
  • Published 1988
  • Biology, Medicine
  • Annals of Human Genetics
  • The data establish linkage in both sexes for LDLR:LW (ž= 8.43 at θ= 0.00) and in the male for LDLR:LU (ž= 3.31 at θ= 0.00) and for LW:APOC2 (ž= 3.90 at θ= 0.00) They confirm LDLR:C3 and APOC2:LU linkage in both sexes, and LW:LU linkage in the male. The loci constitute two tightly linked gene clusters, LDLR, C3, LW and APOC2, LU, SE, distinguished by measurable linkage in female meioses within but not between clusters. Argument is supported for a 19p13.2‐cen position for LW and a long arm… CONTINUE READING
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