The chromosome 10 monosomy common in human melanomas results from loss of two separate tumor suppressor loci.

@article{Robertson1999TheC1,
  title={The chromosome 10 monosomy common in human melanomas results from loss of two separate tumor suppressor loci.},
  author={Gavin P Robertson and Rudolf Herbst and Motoo Nagane and H. J. Huang and Webster K Cavenee},
  journal={Cancer research},
  year={1999},
  volume={59 15},
  pages={3596-601}
}
Alteration of chromosome 10 is common in human melanomas and usually entails the loss of an entire chromosome homologue. Although the reasons for monosomy in cancer has remained obscure, one possibility is that multiple tumor suppressor genes residing on this chromosome must be lost in unison during tumor progression, and this is easier to accomplish by chromosome segregation rather than by multiple mutational and/or deletion events. The localization and identification of these genes has been… CONTINUE READING

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