The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles

@article{Levesque2001TheCK,
  title={The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles},
  author={Aime A. Levesque and Duane A Compton},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={154},
  pages={1135 - 1146}
}
Chromokinesins have been postulated to provide the polar ejection force needed for chromosome congression during mitosis. We have evaluated that possibility by monitoring chromosome movement in vertebrate-cultured cells using time-lapse differential interference contrast microscopy after microinjection with antibodies specific for the chromokinesin Kid. 17.5% of cells injected with Kid-specific antibodies have one or more chromosomes that remain closely opposed to a spindle pole and fail to… CONTINUE READING
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