The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

Abstract

The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repressive chromatin configuration mediated by the retinoblastoma protein and repressor E2F factors changes at the G1/S transition to allow transcription activation is unclear. Here we show ChIP-on-chip studies that reveal that the chromatin remodeller CHD8 binds… (More)
DOI: 10.1093/nar/gkt1161

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