The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.

Abstract

Using conditional gene targeting in mice, we show that the chromatin remodeler Mi-2beta is crucial for different aspects of skin development. Early (E10.5) depletion of Mi-2beta in the developing ventral epidermis results in the delayed reduction of its suprabasal layers in late embryogenesis and to the ultimate depletion of its basal layer. Later (E13.5… (More)

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@article{Kashiwagi2007TheCR, title={The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.}, author={Mariko Kashiwagi and B. A. Morgan and Katia Georgopoulos}, journal={Development}, year={2007}, volume={134 8}, pages={1571-82} }