The chromatin environment shapes DNA replication origin organization and defines origin classes.

@article{Cayrou2015TheCE,
  title={The chromatin environment shapes DNA replication origin organization and defines origin classes.},
  author={Christelle Cayrou and Beno{\^i}t Ballester and Isabelle Peiffer and Romain Fenouil and Philippe Coulombe and Jean-Christophe Andrau and Jacques van Helden and Marcel Méchali},
  journal={Genome research},
  year={2015},
  volume={25 12},
  pages={
          1873-85
        }
}
To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high-resolution in mouse ES cells. This allowed initiation sites (IS) and initiation zones (IZ) to be differentiated. We then characterized their genetic signatures and organization and integrated these data with 43 chromatin marks and factors. Our results reveal that replication origins can be grouped into three main classes with distinct organization, chromatin environment… 

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