The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44

@article{Naujokas1993TheCS,
  title={The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44},
  author={Marisa F. Naujokas and Michelle Morin and Mark S. Anderson and Mary Peterson and Jim Miller},
  journal={Cell},
  year={1993},
  volume={74},
  pages={257-268}
}
Invariant chain (Ii) is a nonpolymorphic glycoprotein that associates with major histocompatibility complex class II molecules and has been shown to mediate several functions in class II-restricted antigen presentation. A small proportion of Ii is modified by the addition of chondroitin sulfate (Ii-CS), and this form of Ii is associated with class II on the surface of antigen-presenting cells. In this report we show that expression of Ii-CS dramatically enhanced the ability of class II-positive… CONTINUE READING
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