The cholinergic system in aging and neuronal degeneration

@article{Schliebs2011TheCS,
  title={The cholinergic system in aging and neuronal degeneration},
  author={Reinhard Schliebs and Thomas Arendt},
  journal={Behavioural Brain Research},
  year={2011},
  volume={221},
  pages={555-563}
}

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  • 2016

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To obtain further insights into the mechanisms of brain plasticity and adult neurogenesis, as the basis for prevention and potential therapeutic options, is a major challenge of modern neurosciences.

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TLDR
It is concluded that the loss of calcium buffering capacity in these neurons and the resultant pathological increase in intracellular calcium are permissive to tangle formation and degeneration.

Contribution of the Cholinergic System to Verbal Memory Performance in Mild Cognitive Impairment

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...

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