The cholinergic system, circadian rhythmicity, and time memory

@article{Hut2011TheCS,
  title={The cholinergic system, circadian rhythmicity, and time memory},
  author={Roelof A. Hut and Eddy van der Zee},
  journal={Behavioural Brain Research},
  year={2011},
  volume={221},
  pages={466-480}
}
  • R. Hut, E. Zee
  • Published 10 August 2011
  • Biology
  • Behavioural Brain Research

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References

SHOWING 1-10 OF 214 REFERENCES

Coupling of Muscarinic Cholinergic Receptors and cGMP in Nocturnal Regulation of the Suprachiasmatic Circadian Clock

TLDR
This study is among the first to identify a functional context for mAChR–cGMP coupling in the CNS and conclude that nocturnal gating of this pathway is controlled by the circadian clock, and a gating site is positioned downstream from cGMP.

Neurotransmitters in the mammalian circadian system.

TLDR
Evidence that the circadian pacemaker in the SCN continues to run, but cannot be entrained by light, when tetrodotoxin is used to block sodium-dependent action potentials is presented, suggesting that classical synaptic neurotransmission is important for entrainment but not for rhythm generation.

Nicotine and nicotinic receptors in the circadian system

Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night

  • C. LiuM. Gillette
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
TLDR
It is demonstrated that carbachol acts directly on the SCN to reset the phase of its firing rhythm during the subjective night via an M1-like mAChR.

Cholinergic modulation of neuronal excitability in the rat suprachiasmatic nucleus.

TLDR
The multiple actions of cholinergic modulation via multiple receptors and ion channels may allow acetylcholine to finely control SCN neuron excitability in different physiological settings.
...