Cholinergic system in sleep regulation of emotion and motivation.
- Psychology, BiologyPharmacological research
Involvement of the cholinergic system in conditioning and perceptual memory
- Psychology, BiologyBehavioural Brain Research
The role of visual cortex acetylcholine in learning to discriminate temporally modulated visual stimuli
- Biology, PsychologyFront. Behav. Neurosci.
In the face of compromised cholinergic input to the VCx, the rats' ability to learn to perform fine discriminations is impaired, whereas their ability to perform previously learned discriminations remains unaffected, suggesting that acetylcholine serves the role of facilitating plastic changes in the sensory cortices that are necessary for an animal to refine its sensitivity to the temporal characteristics of relevant stimuli.
Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates
- Biology, PsychologyNeuropsychopharmacology
Development of M1 PAMs represents a viable strategy for attenuating age-related and dementia-related pathological disturbances of sleep and arousal and produced dose-related increases in high frequency gamma power, a correlate of arousal and cognition enhancement, without altering duration of time across all sleep/wake stages.
Astrocytic IP3/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep
- Biology, PsychologyFront. Neural Circuits
Attenuating IP3/Ca2+ signaling specifically in astrocytes caused mice to spend more time in REM sleep and enter this state more frequently during their inactive phase, and to exhibit greater power in the theta frequency range.
Bidirectional relationships between sleep and amyloid-beta in the hippocampus
- Biology, PsychologyNeurobiology of Learning and Memory
Electroencephalographic prodromal markers of dementia across conscious states in Parkinson's disease.
- Psychology, MedicineBrain : a journal of neurology
It is suggested that electroencephalographic slowing during sleep is a new promising predictive biomarker for Parkinson's disease dementia, perhaps as a marker of cholinergic denervation.
Functional changes in brain oscillations in dementia: a review
- Psychology, BiologyReviews in the neurosciences
Reviewing previous studies investigating changes in brain oscillations associated to the most common types of dementia concluded that neurophysiological changes can be reliable early markers of dementia.
Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity
- Biology, PsychologyFront. Neural Circuits
The evidence that cholinergic modulation of the mPFC plays a role in attention is reviewed, the current knowledge about the role between ACh receptors (AChRs) and behavior is summarized and how ACh receptor activation changes processing in the cortical microcircuitry is summarized.
SHOWING 1-10 OF 40 REFERENCES
Cholinergic modulation of the cortical neuronal network
- Biology, PsychologyPflügers Archiv
The current knowledge on central cholinergic systems (projections and receptors) is summarized and the implications for ACh in the modulation of cortical neuronal activity are focused on.
Basal forebrain acetylcholine release during REM sleep is significantly greater than during waking.
- Biology, PsychologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
The finding that, during REM sleep, basal forebrain ACh release is significantly elevated over waking levels suggests a differential role for basal fore brain ACh duringREM sleep and waking.
Cholinergic Dysfunction in Temporal Lobe Epilepsy
- Biology, PsychologyEpilepsia
It is concluded that while the exact role of cholinergic dysfunction in TLE is not known, there is a firm basis for suggesting that changes in the expression of key cholinerg proteins—and the associated cholinergy dysfunction—are key factors in the basic mechanisms underlying TLE.
Tonic and phasic influence of basal forebrain unit activity on the cortical EEG
- BiologyBehavioural Brain Research
The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease
- Biology, PsychologyJournal of Neural Transmission
Understanding the molecular mechanisms underlying the interrelationship between cortical cholinergic dysfunction, β-amyloid formation and deposition, and tau pathology in Alzheimer’s disease, would allow to derive potential treatment strategies to pharmacologically intervene in the disease-causing signaling cascade.
Electroencephalographic activation by tacrine, deprenyl, and quipazine: cholinergic vs. non-cholinergic contributions.
- Biology, PsychologyEuropean journal of pharmacology
Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG)
- BiologyEuropean Neuropsychopharmacology
State transitions between wake and sleep, and within the ultradian cycle, with focus on the link to neuronal activity.
- Biology, PsychologySleep medicine reviews