The cholinergic system, EEG and sleep

@article{Platt2011TheCS,
  title={The cholinergic system, EEG and sleep},
  author={Bettina Platt and Gernot Riedel},
  journal={Behavioural Brain Research},
  year={2011},
  volume={221},
  pages={499-504}
}
  • B. PlattG. Riedel
  • Published 10 August 2011
  • Biology, Psychology
  • Behavioural Brain Research

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References

SHOWING 1-10 OF 40 REFERENCES

Cholinergic modulation of the cortical neuronal network

The current knowledge on central cholinergic systems (projections and receptors) is summarized and the implications for ACh in the modulation of cortical neuronal activity are focused on.

Neurobiology of REM and NREM sleep.

Basal forebrain acetylcholine release during REM sleep is significantly greater than during waking.

  • J. VázquezH. Baghdoyan
  • Biology, Psychology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2001
The finding that, during REM sleep, basal forebrain ACh release is significantly elevated over waking levels suggests a differential role for basal fore brain ACh duringREM sleep and waking.

Cholinergic Dysfunction in Temporal Lobe Epilepsy

It is concluded that while the exact role of cholinergic dysfunction in TLE is not known, there is a firm basis for suggesting that changes in the expression of key cholinerg proteins—and the associated cholinergy dysfunction—are key factors in the basic mechanisms underlying TLE.

The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease

Understanding the molecular mechanisms underlying the interrelationship between cortical cholinergic dysfunction, β-amyloid formation and deposition, and tau pathology in Alzheimer’s disease, would allow to derive potential treatment strategies to pharmacologically intervene in the disease-causing signaling cascade.