The cholinergic rapid eye movement induction test with arecoline in depression.

@article{Gillin1991TheCR,
  title={The cholinergic rapid eye movement induction test with arecoline in depression.},
  author={John Christian Gillin and Laurent Sutton and Caroline Cubillos Ruiz and John R Kelsoe and Renee M. Dupont and Daniel A Darko and Samuel Craig Risch and Shahrokh Golshan and David S. Janowsky},
  journal={Archives of general psychiatry},
  year={1991},
  volume={48 3},
  pages={
          264-70
        }
}
The cholinergic rapid eye movement (REM) induction test using arecoline hydrobromide, a cholinergic muscarinic receptor agonist, was studied in patients with affective disorder and in normal controls to determine whether or not depression is associated with enhanced induction of REM sleep by muscarinic agonists. Arecoline induced REM sleep in a dose-dependent fashion in both patients and controls compared with placebo infusions. Compared with normal controls, patients entered REM sleep… CONTINUE READING
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