The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development.

@article{Terry2003TheCH,
  title={The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development.},
  author={Alvin V. Terry and Jerry J. Buccafusco},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={306 3},
  pages={821-7}
}
The cholinergic hypothesis was initially presented over 20 years ago and suggests that a dysfunction of acetylcholine containing neurons in the brain contributes substantially to the cognitive decline observed in those with advanced age and Alzheimer's disease (AD). This premise has since served as the basis for the majority of treatment strategies and drug development approaches for AD to date. Recent studies of the brains of patients who had mild cognitive impairment or early stage AD in… CONTINUE READING
259 Extracted Citations
65 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 259 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 65 references

Similar Papers

Loading similar papers…