The cholinergic amacrine cells of rabbit retina receive on and off input: an analysis of [3H]-ACh release using 2-amino-4-phosphonobutyric acid (APB) and chloride free medium.

@article{Massey1983TheCA,
  title={The cholinergic amacrine cells of rabbit retina receive on and off input: an analysis of [3H]-ACh release using 2-amino-4-phosphonobutyric acid (APB) and chloride free medium.},
  author={Stephen C. Massey and Dianna A. Redburn},
  journal={Vision research},
  year={1983},
  volume={23 12},
  pages={1615-20}
}
Using the in vitro rabbit eye-cup we have examined the light-evoked release of ACh from cholinergic amacrine cells under conditions known to eliminate On responses in the retina. APB (100 microM), which blocks the photoreceptor/depolarizing bipolar cell synapse, reduced the light-evoked release of ACh by 80% but a small light-evoked response remained, which was potentiated by bicuculline. Depolarizing bipolar cells are also Cl- dependent. Cl- free medium caused a tenfold Ca2+-dependent increase… CONTINUE READING

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