The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.

@article{Tansley2007TheCT,
  title={The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.},
  author={Gavin H K Tansley and Braydon L. Burgess and Matt T. Bryan and Yuan Su and Veronica Hirsch-Reinshagen and Jonathan Pearce and J. T. Y. Chan and Anna Wilkinson and Jeanette Evans and Kathryn E. Naus and Sean A. McIsaac and Kelley Bromley and Weihong Song and Hsui-Chiung Yang and Nan Wang and Ronald Bradley Demattos and Cheryl L Wellington},
  journal={Journal of lipid research},
  year={2007},
  volume={48 5},
  pages={1022-34}
}
Although intracellular cholesterol levels are known to influence the proteolysis of beta-amyloid precursor protein (APP), the effect of specific genes that regulate cholesterol metabolism on APP processing remains poorly understood. The cholesterol transporter ABCG1 facilitates cholesterol efflux to HDL and is expressed in brain. Notably, the human ABCG1 gene maps to chromosome 21q22.3, and individuals with Down syndrome (DS) typically manifest with Alzheimer's disease (AD) neuropathology in… CONTINUE READING

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