The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.

@article{Ricketts2007TheCF,
  title={The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.},
  author={Marie-Louise Ricketts and Mark V. Boekschoten and Arja J Kreeft and Guido J E J Hooiveld and Corina J. A. Moen and Michael M{\"u}ller and Rune R. Frants and Soemini Kasanmoentalib and Sabine M. Post and Hans M G Princen and J. Gordon Porter and Martijn Bernard Katan and Marten H. Hofker and David D. Moore},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 7},
  pages={1603-16}
}
Cafestol, a diterpene present in unfiltered coffee brews such as Scandinavian boiled, Turkish, and cafetière coffee, is the most potent cholesterol-elevating compound known in the human diet. Several genes involved in cholesterol homeostasis have previously been shown to be targets of cafestol, including cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid biosynthesis. We have examined the mechanism by which cafestol elevates serum lipid levels. Changes in several… CONTINUE READING
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