The cholesterol-dependent cytolysin family of gram-positive bacterial toxins.

  title={The cholesterol-dependent cytolysin family of gram-positive bacterial toxins.},
  author={Alejandro P Heuck and Paul C. Moe and Benjamin B. Johnson},
  journal={Sub-cellular biochemistry},
The cholesterol-dependent cytolysins (CDCs) are a family of beta-barrel pore-forming toxins secreted by Gram-positive bacteria. These toxins are produced as water-soluble monomeric proteins that after binding to the target cell oligomerize on the membrane surface forming a ring-like pre-pore complex, and finally insert a large beta-barrel into the membrane (about 250 A in diameter). Formation of such a large transmembrane structure requires multiple and coordinated conformational changes. The… CONTINUE READING


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