The chlamydial organism Simkania negevensis forms ER vacuole contact sites and inhibits ER-stress.

@article{Mehlitz2014TheCO,
  title={The chlamydial organism Simkania negevensis forms ER vacuole contact sites and inhibits ER-stress.},
  author={Adrian Mehlitz and Karthika Karunakaran and Jo-Ana Herweg and Georg Krohne and Sebastian van de Linde and Elke Rieck and Markus Sauer and Thomas Rudel},
  journal={Cellular microbiology},
  year={2014},
  volume={16 8},
  pages={1224-43}
}
Most intracellular bacterial pathogens reside within membrane-surrounded host-derived vacuoles. Few of these bacteria exploit membranes from the host's endoplasmic reticulum (ER) to form a replicative vacuole. Here, we describe the formation of ER-vacuole contact sites as part of the replicative niche of the chlamydial organism Simkania negevensis. Formation of ER-vacuole contact sites is evolutionary conserved in the distantly related protozoan host Acanthamoeba castellanii. Simkania growth is… CONTINUE READING

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