The chimpanzee model for hepatitis B virus infection.

@article{Wieland2015TheCM,
  title={The chimpanzee model for hepatitis B virus infection.},
  author={S F Wieland},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2015},
  volume={5 6}
}
Even before the discovery of hepatitis B virus (HBV), it was known that chimpanzees (Pan troglodytes) are susceptible to human hepatitis viruses. The chimpanzee is the only primate animal model for HBV infections. Much like HBV-infected human patients, chimpanzees can develop acute and chronic HBV infections and consequent hepatitis. Chimpanzees also develop a cellular immune response similar to that observed in humans. For these reasons, the chimpanzee has proven to be an invaluable model for… CONTINUE READING
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