The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

@inproceedings{Ji2017TheCM,
  title={The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model},
  author={Shundong Ji and Miao Jiang and Bin Yan and Fei Shen and Yang He and Aini Wan and Lijun Xia and Chang-geng Ruan and Yiming Zhao},
  booktitle={Journal of hematology & oncology},
  year={2017}
}
BACKGROUND SZ-123, a murine monoclonal antibody that targets the human von Willebrand factor (VWF) A3 domain and blocks the binding of collagen, is a powerful antithrombotic. In a Rhesus monkey model of thrombosis, SZ-123 had no side effects, such as bleeding or thrombocytopenia. METHODS The mouse/human chimeric version of SZ-123, MHCSZ-123, was developed… CONTINUE READING