The chick embryo in toxicology: an alternative to the rabbit eye.

@article{Leighton1985TheCE,
  title={The chick embryo in toxicology: an alternative to the rabbit eye.},
  author={Joseph Leighton and J Nassauer and Ruy Tchao},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1985},
  volume={23 2},
  pages={293-8}
}
The chorioallantoic membrane (CAM) of the chick embryo is readily accessible for experimentation. It is a complete tissue that responds to injury with classical inflammatory reactions. It is limited to the late phase of embryologic life, and is without the sense of pain. Focal topical application of various household products onto the CAM results in local injury and reactions that differ in severity from one product to another. For any single product, tested as a sequence of dilutions on a… CONTINUE READING