The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.

@article{Carrodeguas2005TheCE,
  title={The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.},
  author={Jos{\'e} A Carrodeguas and Annie Rodolosse and M. Valdez Garza and Antonio Sanz-Clemente and Rosaura P{\'e}rez-P{\'e} and Ana Ma Lacosta and Laura Dominguez and Inmaculada Monle{\'o}n and Raquel S{\'a}nchez-D{\'i}az and Vı́ctor Sorribas and M Arraiza Sarasa},
  journal={Neuroscience},
  year={2005},
  volume={134 4},
  pages={1285-300}
}
This study reveals that the chick embryo has active the machinery for the production and degradation of the amyloid beta peptide characteristic of Alzheimer's disease. We cloned the principal beta-amyloid precursor protein isoforms in the chick embryo and observed that they are highly homologous to the human sequences and identical at the C-terminal sequence, including the amyloid beta domain. Mammals such as rat or mouse, more commonly used as animal models of human diseases, have a distinct… CONTINUE READING
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