The chick chorioallantoic membrane as a novel in vivo model for the testing of biomaterials.

@article{Valdes2002TheCC,
  title={The chick chorioallantoic membrane as a novel in vivo model for the testing of biomaterials.},
  author={Thelma I Valdes and Don L. Kreutzer and Francis Moussy},
  journal={Journal of biomedical materials research},
  year={2002},
  volume={62 2},
  pages={
          273-82
        }
}
Current in vivo models for testing biomaterials are time and labor intensive as well as expensive. This article describes a new approach for testing biomaterials in vivo using the chorioallantoic membrane (CAM) of the developing chicken embryo, as an alternative to the traditional mammalian models. Fertilized chicken eggs were incubated for 4 days, at which time a small window was cut in the shell of the egg. After 1 week of incubation, the CAM received several test materials, including the… CONTINUE READING
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