The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain

@article{Vo2013TheCA,
  title={The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain},
  author={T. Vo and D. Carulli and E. Ehlert and Jessica C F Kwok and J. Verhaagen},
  journal={Molecular and Cellular Neuroscience},
  year={2013},
  volume={56},
  pages={186-200}
}
  • T. Vo, D. Carulli, +2 authors J. Verhaagen
  • Published 2013
  • Biology, Medicine
  • Molecular and Cellular Neuroscience
  • In the adult rodent brain, subsets of neurons are surrounded by densely organised extracellular matrix called perineuronal nets (PNNs). PNNs consist of hyaluronan, tenascin-R, chondroitin sulphate proteoglycans (CSPGs), and the link proteins Crtl1 and Bral2. PNNs restrict plasticity at the end of critical periods and can be visualised with Wisteria floribunda agglutinin (WFA). Using a number of antibodies raised against the different regions of semaphorin3A (Sema3A) we demonstrate that this… CONTINUE READING
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