The chemopreventive activity of apple against carcinogenesis: antioxidant activity and cell cycle control

  title={The chemopreventive activity of apple against carcinogenesis: antioxidant activity and cell cycle control},
  author={Fl{\'a}via Andressa Pidone Ribeiro and Carolina Foot Gomes de Moura and Odair Aguiar and Flavia de Oliveira and Regina C{\'e}lia Spadari and Nara Rejane Cruz de Oliveira and Celina Tizuko Fujiyama Oshima and Daniel Araki Ribeiro},
  journal={European Journal of Cancer Prevention},
Apples and their derivatives are rich in phytochemicals, including flavonoids (catechins, flavonols, quercetin) and phenolic acids (quercetin glycosides, catechin, epicatechin, procyanidins), vitamins, and fibers, that confer an important antioxidant property. Chemoprevention is defined by the use of natural or synthetic agents to interfere with the progression, reverse, or inhibit carcinogenesis, thereby reducing the risk of developing clinically invasive disease. The aim of this article is to… 
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Cancer chemopreventive potential of apples, apple juice, and apple components.
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Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation.
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  • 2003
It is reported here that apple extracts did not induce H( 2)O(2) formation in WME, DMEM, or DMEM/Ham F12 media with the cell culture conditions tested, and antiproliferative activity of apple extracts was not due to the phenolic-induced H(2,O,2) production in cell culture media.
Antioxidant and antiproliferative activities of common fruits.
A bioactivity index (BI) for dietary cancer prevention is proposed to provide a new alternative biomarker for future epidemiological studies in dietary cancer Prevention and health promotion.
Potential synergy of phytochemicals in cancer prevention: mechanism of action.
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A recommendation that consumers eat 5 to 10 servings of a wide variety of fruits and vegetables daily is an appropriate strategy for significantly reducing the risk of chronic diseases and to meet their nutrient requirements for optimum health.
Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?
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Several polyphenolic compounds, which are commonly found in vegetables, fruits and plant-derived juices or beverages, exert well-evidenced cardioprotective, neuroprotective, chemopreventive and anti-inflammatory properties, but, nevertheless, further clinical and epidemiological research is required.
Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics
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