The chemopreventive activity of apple against carcinogenesis: antioxidant activity and cell cycle control

@article{Ribeiro2014TheCA,
  title={The chemopreventive activity of apple against carcinogenesis: antioxidant activity and cell cycle control},
  author={Fl{\'a}via Andressa Pidone Ribeiro and Carolina Foot Gomes de Moura and Odair Aguiar and Flavia de Oliveira and Regina C{\'e}lia Spadari and Nara Rejane Cruz de Oliveira and Celina Tizuko Fujiyama Oshima and Daniel Araki Ribeiro},
  journal={European Journal of Cancer Prevention},
  year={2014},
  volume={23},
  pages={477–480}
}
Apples and their derivatives are rich in phytochemicals, including flavonoids (catechins, flavonols, quercetin) and phenolic acids (quercetin glycosides, catechin, epicatechin, procyanidins), vitamins, and fibers, that confer an important antioxidant property. Chemoprevention is defined by the use of natural or synthetic agents to interfere with the progression, reverse, or inhibit carcinogenesis, thereby reducing the risk of developing clinically invasive disease. The aim of this article is to… 
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TLDR
The selective cytotoxicity of AF4 for breast cancer cells, combined with the capacity of sub-cytotoxic AF4 to inhibit breast cancer cell proliferation, migration, and invasion suggests that flavonoid-rich AF4 (and its constituents) has potential as a natural therapeutic agent for Breast cancer treatment.
Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats.
A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer
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The hypothesis that chemo-preventive effects of apple extracts in human pathologies, in particular for colorectal cancer, may be the interference with the activity of nucleotide metabolism and methylation enzymes, similarly to some classes of anticancer drugs is suggested.
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TLDR
It is demonstrated that concentrated apple extract was able to interfere with either intrinsic or extrinsic apoptotic pathways in the colon of rats with colitis.
Molecular simulations for investigating the role of food polyphenols in human health
TLDR
This study evidenced possible protein targets found in apple but present also in other fruits and vegetables as well as molecular simulations of protein-ligand docking, mutation effects, pathways analysis, and bioinformatics resources for collecting information about proteins and their structural and functional properties.
Multifaceted analyses disclose the role of fruit size and skin-russeting in the accumulation pattern of phenolic compounds in apple
TLDR
It is suggested that specific white-fleshed apples, especially with russeted-skin, may play an important role in ameliorating the nutraceutical potential of apple fruit.
Review on Preclinical and Clinical Evidence of Food (Beverages, Fruits and Vegetables) and Drug Interactions: Mechanism and Safety
TLDR
It can be concluded that the interaction of food with drug(s) significantly alters their therapeutic potential and the inputs from clinical practitioners to elucidate potential risk of food-drug interaction need to be intensified in order to prevent adverse clinical consequences.
Evidence-based review on anticancer effects of commonly used herbs
TLDR
The phytochemicals and evidence-based preventive and therapeutic effects of some commonly used plants with medicinal properties against cancer are reviewed.
Review of Phytochemical and Pharmacological Effects of Apple
TLDR
Apple has a high nutritional value so that it can be a good food source and pharmacologically, this fruit is reported to have Antioxidants, Antiobesity, Anticholesterol, Anticancer, Enzyme Inhibitor and Antimicrobial.
An apple plus a Brazil nut a day keeps the doctors away: antioxidant capacity of foods and their health benefits.
TLDR
Based on the high TAC content of Brazil nuts, guaraná, coffee, chocolate, collard greens, apples, beets, beans, oranges, onions and other foods, their regular dietary intake is strongly recommended to reduce the risk of chronic non-communicable diseases.
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