The chemokine system: a possible therapeutic target in acute graft versus host disease.

@article{Kittan2010TheCS,
  title={The chemokine system: a possible therapeutic target in acute graft versus host disease.},
  author={Nicolai A Kittan and Gerhard C. Hildebrandt},
  journal={Current topics in microbiology and immunology},
  year={2010},
  volume={341},
  pages={97-120}
}
Allogeneic hematopoetic stem cell transplantation often presents the only chance for cure in a number of malignant and nonmalignant hematologic diseases. However, its beneficial effects are counterweighed by the development of potentially lethal complications, most importantly the development of acute and chronic graft-vs.-host disease (GVHD). Alloantigen-reactive immune responses mediate injury and destruction of GVHD target organs, including the gastrointestinal tract, the liver, the skin… CONTINUE READING

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