The chemokine superfamily revisited.

  title={The chemokine superfamily revisited.},
  author={Albert Zlotnik and Osamu Yoshie},
  volume={36 5},
The chemokine superfamily consists of a large number of ligands and receptors. At first glance, this family appears redundant and their ligand-receptor relationships promiscuous, making its study challenging. However, analyzing this family from the evolutionary perspective greatly simplifies understanding both the organization and function of this apparently complex system. In particular, the functions of a subgroup of chemokines (designated homeostatic chemokines) have played pivotal roles in… CONTINUE READING
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