The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia.

@article{Thomas2008TheCR,
  title={The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia.},
  author={Ryan M Thomas and Jae W Kim and Monica P. Revelo-Penafiel and Rebecca E. De Angel and David W. Dawson and Andrew M. Lowy},
  journal={Gut},
  year={2008},
  volume={57 11},
  pages={
          1555-60
        }
}
OBJECTIVE The chemokine CXCL12, together with its specific receptor, CXCR4, have been shown to mediate invasiveness and metastatic behaviour in pancreatic cancer cells. The expression of CXC12/CXCR4 has not been previously examined in pancreatic intraepithelial neoplasias (PanIN), the accepted precursor lesions to pancreatic duct cancer. DESIGN In this study we sought to characterise the expression of CXCL12 and CXCR4 during the progression of PanIN using both a murine model and human tissues… CONTINUE READING
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