The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis.

@article{Ritzman2010TheCR,
  title={The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis.},
  author={Anna M Ritzman and Jennifer M Hughes-Hanks and Victoria Blaho and Laura E Wax and William J. Mitchell and Charles R Brown},
  journal={Infection and immunity},
  year={2010},
  volume={78 11},
  pages={4593-600}
}
Deletion of the chemokine receptor CXCR2 prevents the recruitment of neutrophils into tissues and subsequent development of experimental Lyme arthritis. Following footpad inoculation of Borrelia burgdorferi, the agent of Lyme disease, expression of the CXCR2 ligand KC (CXCL1) is highly upregulated in the joints of arthritis-susceptible mice and is likely to play an important role in the recruitment of neutrophils to the site of infection. To test this hypothesis, we infected C3H KC(-/-) mice… CONTINUE READING
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ROLE OF KC/CXCR2 IN LYME BORRELIOSIS 4599 on A ril

  • A. E. Koch, S. L. Kunkel, L. A. Harlow, D. D. Mazarakis, G. K. Haines
  • J. Clin. Invest
  • 2010

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