The chemokine receptor CXCR 3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP 10 and Mig

@inproceedings{Piali1998TheCR,
  title={The chemokine receptor CXCR 3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP 10 and Mig},
  author={Luca Piali and Christian Weber and G. Larosa and Charles R Mackay and Timothy A Springer and I Clark-lewis and Bernhard Moser},
  year={1998}
}
Integrin-mediated adhesion to the vascular endothelium is an essential step in leukocyte diapedesis. We show that the chemokines 10-kDa inflammatory protein (IP10) and monokine induced by IFN (Mig) induce rapid and transient adhesion of human IL-2-stimulated T lymphocytes (IL-2 T cells) to immobilized integrin ligands through their receptor CXCR3, which is selectively expressed on activated T cells. Induction of adhesion by IP10 and Mig was already observed at subnanomolar concentrations and… CONTINUE READING
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