The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells

@article{Boyle2016TheCR,
  title={The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells},
  author={Sarah T Boyle and Wendy V. Ingman and Viktor V. Poltavets and Jessica W. Faulkner and Robert J Whitfield and Shaun R McColl and Marina Kochetkova},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={105-115}
}
The chemokine receptor CCR7 is widely implicated in breast cancer pathobiology. Although recent reports correlated high CCR7 levels with more advanced tumor grade and poor prognosis, limited in vivo data are available regarding its specific function in mammary gland neoplasia and the underlying mechanisms involved. To address these questions we generated a bigenic mouse model of breast cancer combined with CCR7 deletion, which revealed that CCR7 ablation results in a considerable delay in tumor… CONTINUE READING
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