The chemokine network in cancer--much more than directing cell movement.

  title={The chemokine network in cancer--much more than directing cell movement.},
  author={Hagen Kulbe and Neil R Levinson and Frances R. Balkwill and Julia L. Wilson},
  journal={The International journal of developmental biology},
  volume={48 5-6},
Cytokine and chemokine gradients are central to the directed movement of cells in both homeostatic and pathological processes. Most cancers have a complex chemokine network which can influence immune responses to the tumor, direct the extent and cellular composition of the leukocyte infiltrate and also play a role in angiogenesis. Tumor cells can also hijack the chemokine system and gain expression of certain chemokine receptors and respond to specific chemokine gradients. Chemokine receptor… CONTINUE READING


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