The chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications.

@article{Kittang2010TheCN,
  title={The chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications.},
  author={Astrid Olsnes Kittang and Kimberley Joanne Hatfield and Kristoffer Sand and H{\aa}kon Reikvam and \Oystein Bruserud},
  journal={Current topics in microbiology and immunology},
  year={2010},
  volume={341},
  pages={149-72}
}
Acute myelogenous leukemia (AML) is a bone marrow disease in which the leukemic cells show constitutive release of a wide range of CCL and CXCL chemokines and express several chemokine receptors. The AML cell release of various chemokines is often correlated and three release clusters have been identified: CCL2-4/CXCL1/8, CCL5/CXCL9-11, and CCL13/17/22/24/CXCL5. CXCL8 is the chemokine usually released at highest levels. Based on their overall constitutive release profile, patients can be… CONTINUE READING