The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival.

  title={The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival.},
  author={Kathleen A Molyneaux and H{\'e}l{\`e}ne Zinszner and Prabhat S. Kunwar and Kyle Schaible and Juerg Stebler and Mary Jean Sunshine and William J. O'Brien and Erez Raz and Dan K. Littman and Chris C Wylie and Ruth Lehmann},
  volume={130 18},
In mouse embryos, germ cells arise during gastrulation and migrate to the early gonad. First, they emerge from the primitive streak into the region of the endoderm that forms the hindgut. Later in development, a second phase of migration takes place in which they migrate out of the gut to the genital ridges. There, they co-assemble with somatic cells to form the gonad. In vitro studies in the mouse, and genetic studies in other organisms, suggest that at least part of this process is in… CONTINUE READING
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