The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.

@article{Peled2000TheCS,
  title={The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.},
  author={Amnon Peled and Orit Kollet and Tatyana Ponomaryov and Isabelle Petit and Suzana Franitza and Valentin Grabovsky and M M Slav and Arnon Nagler and Ofer Lider and Ronen Alon and Dov Zipori and Tsvee Lapidot},
  journal={Blood},
  year={2000},
  volume={95 11},
  pages={3289-96}
}
Hematopoietic stem cell homing and engraftment require several adhesion interactions, which are not fully understood. Engraftment of nonobese/severe combined immunodeficiency (NOD/SCID) mice by human stem cells is dependent on the major integrins very late activation antigen-4 (VLA-4); VLA-5; and to a lesser degree, lymphocyte function associated antigen-1 (LFA-1). Treatment of human CD34(+) cells with antibodies to either VLA-4 or VLA-5 prevented engraftment, and treatment with anti-LFA-1… CONTINUE READING
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