The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS.

@article{Henkel2006TheCM,
  title={The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS.},
  author={Jenny S. Henkel and David R. Beers and L{\'a}szl{\'o} Sikl{\'o}s and Stanley H. Appel},
  journal={Molecular and cellular neurosciences},
  year={2006},
  volume={31 3},
  pages={427-37}
}
We recently demonstrated increased dendritic cells (potent antigen-presenting cells) and MCP-1 (monocyte, T-cell, and dendritic cell attracting chemokine) levels in ALS spinal cord tissue. Additionally, we presented data suggesting that dendritic cells might be contributing to the pathogenesis. To determine whether MCP-1 and dendritic cells are present in the mSOD1 mouse and how early in the disease process they are involved, we examined mSOD1 and control spinal cord tissue at different ages… CONTINUE READING

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