The chemistry of single-stranded 4'-DNA radicals: influence of the radical precursor on anaerobic and aerobic strand cleavage.

@article{Giese1995TheCO,
  title={The chemistry of single-stranded 4'-DNA radicals: influence of the radical precursor on anaerobic and aerobic strand cleavage.},
  author={Bernd Giese and X Beyrich-Graf and Prof. Dr. Erland Erdmann and Mario Petretta and U Schwitter},
  journal={Chemistry & biology},
  year={1995},
  volume={2 6},
  pages={367-75}
}
BACKGROUND Deoxyribosylnucleotide radicals with a radical center at the 4'-position are important intermediates in radical-induced DNA strand cleavage. In the presence of O2, these DNA radicals yield cleavage products that are partly oxidized. In the past, the postulated peroxide intermediates could not be detected directly because they were unstable under… CONTINUE READING