The chemistry and pharmacology of privileged pyrroloquinazolines.

@article{Chao2015TheCA,
  title={The chemistry and pharmacology of privileged pyrroloquinazolines.},
  author={Bo Chao and Bingbing X. Li and Xiangshu Xiao},
  journal={MedChemComm},
  year={2015},
  volume={6 4},
  pages={510-520}
}
The advent of next-generation sequencing (NGS) technology has plummeted the cost of whole genome sequencing, which has provided a long list of putative drug targets for a variety of diseases ranging from infectious diseases to cancers. The majority of these drug targets are still awaiting high-quality small molecule ligands to validate their therapeutic potential and track their druggability. Screening compound libraries based on privileged scaffolds is an efficient strategy to identify… CONTINUE READING
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