The chemically inducible plant cytochrome P450 CYP76B1 actively metabolizes phenylureas and other xenobiotics

@article{Robineau1998TheCI,
  title={The chemically inducible plant cytochrome P450 CYP76B1 actively metabolizes phenylureas and other xenobiotics},
  author={Robineau and Batard and Nedelkina and Cabello-Hurtado and LeRet and Sorokine and Didierjean and Werck-Reichhart},
  journal={Plant physiology},
  year={1998},
  volume={118 3},
  pages={
          1049-56
        }
}
  • Robineau, Batard, +5 authors Werck-Reichhart
  • Published 1998
  • Biology, Medicine
  • Plant physiology
    • Cytochrome P450s (P450s) constitute one of the major classes of enzymes that are responsible for detoxification of exogenous molecules both in animals and plants. On the basis of its inducibility by exogenous chemicals, we recently isolated a new plant P450, CYP76B1, from Jerusalem artichoke (Helianthus tuberosus) and showed that it was capable of dealkylating a model xenobiotic compound, 7-ethoxycoumarin. In the present paper we show that CYP76B1 is more strongly induced by foreign compounds… CONTINUE READING
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