The chemical synapse goes electric: Ca<ce:sup loc=post>2+</ce:sup>- and voltage-sensitive GPCRs control neurotransmitter release

@article{Parnas2007TheCS,
  title={The chemical synapse goes electric: Ca<ce:sup loc=post>2+</ce:sup>- and voltage-sensitive GPCRs control neurotransmitter release},
  author={Hanna Parnas and Itzchack Parnas},
  journal={Trends in Neurosciences},
  year={2007},
  volume={30},
  pages={54-61}
}
It is widely believed that the initiation of transmitter release in fast synapses is triggered by rapid Ca entry and that the termination of release is governed by removal of Ca from below the release sites. We argue that, although Ca is essential for release, fast-entry kinetics render Ca incapable of being the limiting factor for the initiation of release, and the relatively slow removal of Ca cannot be the limiting factor for the termination of release. We suggest, and provide supporting… CONTINUE READING

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