The chemical repertoire of natural ribozymes

@article{Doudna2002TheCR,
  title={The chemical repertoire of natural ribozymes},
  author={Jennifer A. Doudna and Thomas R. Cech},
  journal={Nature},
  year={2002},
  volume={418},
  pages={222-228}
}
Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity — they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages… 

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