The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.

@article{daSilva2011TheCC,
  title={The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.},
  author={Wagner S da-Silva and Scott A Ribich and Rafael Arrojo e Drigo and Melany Castillo and M F Patti and Antonio Carlos Mugayar Bianco},
  journal={FEBS letters},
  year={2011},
  volume={585 3},
  pages={539-44}
}
Exposure of cell lines endogenously expressing the thyroid hormone activating enzyme type 2 deiodinase (D2) to the chemical chaperones tauroursodeoxycholic acid (TUDCA) or 4-phenylbutiric acid (4-PBA) increases D2 expression, activity and T3 production. In brown adipocytes, TUDCA or 4-PBA induced T3-dependent genes and oxygen consumption (∼2-fold), an effect partially lost in D2 knockout cells. In wild type, but not in D2 knockout mice, administration of TUDCA lowered the respiratory quotient… CONTINUE READING
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