The chemical biology of immunophilin ligands.

@article{Gaali2011TheCB,
  title={The chemical biology of immunophilin ligands.},
  author={S. Gaali and R. Gopalakrishnan and Y. Wang and C. Kozany and F. Hausch},
  journal={Current medicinal chemistry},
  year={2011},
  volume={18 35},
  pages={
          5355-79
        }
}
The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their immunosuppressive properties and their clinical use in transplantation medicine. These compounds or their analogs are also clinically used or investigated in various types of cancer, coronary angioplasty, dermatology, hepatitis C infections, and neuroprotection. Furthermore, the role of immunophilins in various pathologies is increasingly being recognized, supporting the preclinical drug development for novel… Expand
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